I have written a C# dot net application that updates the SMTP relay restriction list in IIS 6. Running the application locally works great and I can add/remove IPs/DNS from the relay restriction list without any problem. Now I need to do the same for a SMTP server that is not running on the same webserver that I have the application running. So I have the web application on webserver A and the SMTP server on webserver/smtp server B. My app pool is running under a domain user and I have given the same user rights to the SMTP server under the security tab in the SMTP Virtual Server property window. I thought I could simply change the sMetabasePath from "IIS://localhost/smtpsvc/1" to "IIS://10.171.243.134/smtpsvc/1" and everything would just work but I get an "Access is denied" error. So I must have to do something else to get this to work. I even gave the domain user full admin rights on the SMTP server to no avail.

Any ideas