What advantage (if any) is there to using typedef in place of #define in C code?

As an example, is there any advantage to using

typedef unsigned char UBYTE

over

#define UBYTE unsigned char

when both can be used as

void func()
{
        UBYTE byte_value = 0;

        /* Do some stuff */

        return byte_value;
}

Obviously the pre-processor will try to expand a #define wherever it sees one, which wouldn't happen with a typedef, but that doesn't seem to me to be any particular advantage or disadvantage; I can't think of a situation where either use wouldn't result in a build error if there was a problem.