I'm sure this has been asked before, but I can't find it.

What are the benefits/limitations of using a browser-based interface for a stand-alone application vs. using a normal GUI framework?

I'm working on a Python program currently implement with wxPython for the GUI. The application is simply user-entry forms and dialogs. I am considering moving to PyQt because of the widgets it has (for future expansion), then I realized I could probably just use a browser to do much of the same stuff.

The application currently doesn't require Internet access, though it's a possibility in the future. I was thinking of using Karrigell for the web framework if I go browser-based.

Edit For clarification, as of right now the application would be browser-based, not web-based. All the information would be stored locally on the client computer; no server calls would need to be made and no Internet access required (it may come later though). It would simply be a browser GUI instead of a wxPython/PyQt GUI. Hope that makes sense.