what is means of this problem when sending email through web-application

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Published on 2010-04-29T12:09:17Z Indexed on 2010/04/29 12:17 UTC
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i have this error when i sending email through our web application " Mailbox unavailable. The server response was: Requested action not taken: mailbox unavailable or not local"

this is detail of error

System.Net.Mail.SmtpFailedRecipientException was caught
  Message=Mailbox unavailable. The server response was: Requested action not taken: mailbox unavailable or not local
  Source=System
  FailedRecipient=<[email protected]>
  StackTrace:
       at System.Net.Mail.SmtpTransport.SendMail(MailAddress sender, MailAddressCollection recipients, String deliveryNotify, SmtpFailedRecipientException& exception)
       at System.Net.Mail.SmtpClient.Send(MailMessage message)
       at email.Globals.SendMail(String EmailID, String subject, String message, String senderMail) in C:location
  InnerException: 

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