I am in the planning stages of rewriting an Access db I wrote several years ago in a full fledged program. I have very slight experience coding, but not enough to call myself a programmer by far. I'll definitely be learning as I go, so I'd like to keep everything as simple as possible. I've decided on Python and SQLite for my program, but I need help on my next decision.

Here is my situation

1) It'll be a desktop program, run locally on each machine, all Windows

2) I want a nice looking GUI with colors, different shaped buttons, nice menus, lists, etc, etc

3) I'm thinking about using a browser interface because (a) from what I've read, browser apps can look really great, and (b) I understand there are lots of free tools to assist in setting up the GUI/GUI code with drag and drop tools, so that helps my "keep it simple" goal.

4) I want the program to be totally portable so it runs completely from one single folder on a user's PC.

If I do go the browser app router, a major concern I have is the possibility that a user's browser settings could affect or break the app. How likely is this?

What other pros and cons are there for my situation?