I have a really specific machine configuration in the works that would really be helped out if there were any way to do this...basically what I'm looking for is the opposite of setting CPU Affinity for a process. I want to be able to tell Windows "No applications except [x] are allowed on [these cores]."

Is there any mechanism whatsoever for doing this? (Yes, I am aware of some of the potential issues this could cause and I normally would never fool with processor affinities, since the OS usually does a damned good job itself, but this is a pretty odd situation involving some software that is very CPU-bound constantly having to wait on interrupts and DPCs and things from other threads.)