Finishing up development work for a client and they have a late request to superscript every occurrence of the &reg character throughout the site. I merely get by with CSS, but not even sure CSS provides the best solution here. how can I make a global change to every occurrence of a single character in the site copy without going back and adding tags everywhere?

if the best solution does involve inserting a span or other tag I'm thinking it could be accomplished with a database query (all the copy is wired up to a CMS).