In GNU screen, I want to change the default command binding to Alt-s (by tweaking .screenrc) instead of the default C-a, the reason is I use emacs hence GNU screen binds the C-a key, sending "C-a" to the emacs becomes tedious (as @Nils said, to send "C-a" I should type "C-a a"), as well as "C-a" in bash shell, and I could change the escape to C- but some of them are already mapped in emacs and other combinations are not as easy as ALT-s . If anyone has already done a ALT key mapping, please do let me know.