When updating any software product, as well as manually trying to replace .exe files, it says that access is denied to the file and in fact the System process is holding a handle to the file when I check it with Process Explorer.

This must be a driver or something that is malfunctioning was my first though, but now I wonder how I figure out which driver / program is doing this and why it is so. Unlocker doesn't seem to be working for me, unless someone can tell me how to use it properly other than making it appear a magical wand in the notification area....

This is what Unlocker puts in my event log:

The description for Event ID 1060 from source Application Popup cannot be found. Either the component that raises this event is not installed on your local computer or the installation is corrupted. You can install or repair the component on the local computer.

If the event originated on another computer, the display information had to be saved with the event.

The following information was included with the event:

\??\C:\Program Files (x86)\Unlocker\UnlockerDriver5.sys

the message resource is present but the message is not found in the string/message table

Upon searching event 1060 I get:

<file name> has been blocked from loading due to incompatibility with this system.

Perhaps it is because I have 64 bit?