So I have several large text files I need to sort through, and remove all occurrences of lines which contain a given keyword. So basically, if I have these lines:

This is not a test
This is a test
Maybe a test
Definitely not a test

And I run the script with 'not', I need to entirely delete lines 1 and 4.

I've been trying with:

PS C:\Users\Admin> (Get-Content "D:\Logs\co2.txt") | 
Foreach-Object {$_ -replace "3*Program*", ""} | 
Set-Content "D:\Logs\co2.txt"

but it only replaces the 'Program' and not the entire line.