I can't get my server to obey the settings from php.ini (I'm trying to change memory_limit and upload_max_filesize). As far as I can tell, I'm editing the correct file. phpinfo() gives:

Loaded Configuration File   /etc/php.ini

The file permission is 644. There are also some extra .ini files on /etc/php.d, but none include any of the keys I'm trying to change. No matter what I do, phpinfo reports the default values on both "Local" and "Master" columns.

I also scanned my Apache config files, but found nothing related to PHP (besides loading the PHP module). The only way I was able to change those settings was by adding some php_value lines to my .htaccess.

Is there something obvious I'm missing?

This is a virtual server, and I can perform root commands with sudo. I'm running Apache 2.1.3 and PHP 5.3.3. System info (from uname -a) is:

 Linux sesctbapp01 2.6.18-308.1.1.el5 #1 SMP Wed Mar 7 04:16:51 EST 2012 x86_64