This question has been asked and the answer given seemed to work for others who asked it, but it doesn't work for me. Here's what happened: the other day my power blinked twice within seconds and it caused my computer to reboot. Ever since then, I get a prompt from Outlook 2010 asking me to choose a profile, either when I load the program or when the program is not even running. The only option is "Outlook", and even when I check "set as default" it keeps asking me. I went to Windows (Vista) Control Panel, and searched for "mail" as someone suggested. The only search result that seemed relevant was "Change default programs that Windows uses". From there, I choose Custom/Choose a default email program/Outlook. There is nothing regarding "profiles" as the forum answer suggests, and it doesn't solve the problem. Also, I did all of this while Outlook was not running. Can someone help?