There are many grids and framework to choose from. A Google search for CSS frameworks will return a dozen articles that themselves list a number of frameworks to choose from.

When it comes to choosing one, it's easy to be lost without having an intimate knowledge of all of them.

What are the main factors that go into choosing a CSS framework, and how will those choices map to certain frameworks?

More generally, how does one choose a CSS framework?

Note 1: I'm using "grid" and "framework" almost interchangeably here, but there is probably one I should use over the other. Corrections on this are welcome.

Note 2: I am well aware that some choices will depend on taste and accordingly, this question can turn into a "best of" contest/subjective topic. I'm trying to keep it as answerable as possible, as I'm pretty sure many have this problem/question of choosing a framework and an answer to that would benefit the community. As such, improvements to this question are welcome rather than just closing it.