My mouse is stuck in "drag" mode. This generally happens in Photoshop, but happens dragging files and such as well.

Clicking rapidly here and there generally solves the problem. Sometimes though, it won't go away until a restart. Unplugging devices, etc., doesn't do anything.

For example, right now, my mouse moves but can not click anything so I am using the keyboard to navigate this site.

Is there a way to "reset" however the OS stores mouse states?

Can I manually fire off a MouseUp event?

It's strange that even when human input devices are unplugged, the files are still in drag state.