I've spent the past few years working on iOS apps, and I'm now giving some serious consideration to creating an Android port of one of my apps.

I'm sure that complaints about fragmentation are a frustrating cliche to experienced Android programmers, but as an iOS programmer, I'm quite honestly overwhelmed by the number of configurations and devices that my app might end up running on.

There are literally thousands of Android devices in the wild, but I know there are successful Android developers in the world and I know they're not testing or developing for thousands of different devices.

So how can a relatively small company deal with fragmentation? Is it possible to pick the five or six most popular devices, focus on those and prevent the app from being installed on any other devices? Are there any other strategies for practically dealing with the number of different configurations an app will face?