Well works fine on my dev machine. Deploys fine from visual studio 2010 using msdeploy to IIS 7.5 with a site named apps.mydomain.com/myapp. So essentially I want to browse to http://apps.mydomain.com/myapp but when I do I get 404 error.

• I have Windows authentication enabled only on the site everything else is disabled.
• I have installed hotfix http://support.microsoft.com/kb/980368.
• App pool .NET 4 integrated pipeline. I have tried classic pipeline also but doesn't work. Edit 2
• executed %windir%\Microsoft.NET\Framework64\v4.0.30319\aspnet_regiis.exe -ir still doesn't work

What am I doing wrong or do I need to do anything else?

Global.asax

public class MvcApplication : System.Web.HttpApplication
{
    public static void RegisterGlobalFilters(GlobalFilterCollection filters)
    {
        filters.Add(new AuthorizeAttribute());
        filters.Add(new HandleErrorAttribute());
    }

    public static void RegisterRoutes(RouteCollection routes)
    {
        routes.IgnoreRoute("{resource}.axd/{*pathInfo}");            
        routes.IgnoreRoute("{*favicon}", new { favicon = @"(.*/)?favicon.ico(/.*)?" });      

        routes.MapRoute(
            "Default", // Route name
            "{controller}/{action}/{id}", // URL with parameters
            new { controller = "Home", action = "Index", id = UrlParameter.Optional } // Parameter defaults
        );
    }

    protected void Application_Start()        
    {
        AreaRegistration.RegisterAllAreas();

        RegisterGlobalFilters(GlobalFilters.Filters);
        RegisterRoutes(RouteTable.Routes);
    }     
}

Web.config

    <?xml version="1.0" encoding="utf-8"?>
<configuration>
  <configSections>
    <section name="entityFramework" type="System.Data.Entity.Internal.ConfigFile.EntityFrameworkSection, EntityFramework, Version=4.4.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089" requirePermission="false" />
    <sectionGroup name="elmah">
      <section name="security" requirePermission="false" type="Elmah.SecuritySectionHandler, Elmah" />
      <section name="errorLog" requirePermission="false" type="Elmah.ErrorLogSectionHandler, Elmah" />
      <section name="errorMail" requirePermission="false" type="Elmah.ErrorMailSectionHandler, Elmah" />
      <section name="errorFilter" requirePermission="false" type="Elmah.ErrorFilterSectionHandler, Elmah" />
    </sectionGroup>
  </configSections>
  <appSettings>
    <add key="webpages:Version" value="1.0.0.0" />
    <add key="ClientValidationEnabled" value="true" />
    <add key="UnobtrusiveJavaScriptEnabled" value="true" />
    <add key="elmah.mvc.disableHandler" value="false" />
    <add key="elmah.mvc.disableHandleErrorFilter" value="false" />
    <add key="elmah.mvc.requiresAuthentication" value="false" />
    <add key="elmah.mvc.allowedRoles" value="*" />
    <add key="elmah.mvc.route" value="elmah" />
    <add key="autoFormsAuthentication" value="false" />
    <add key="enableSimpleMembership" value="false" />
  </appSettings>
  <system.web>
    <customErrors mode="On" defaultRedirect="~/error">
      <error statusCode="404" redirect="~/error/notfound"></error>
    </customErrors>
    <compilation debug="true" targetFramework="4.0">
      <assemblies>
        <add assembly="System.Web.Abstractions, Version=4.0.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35" />
        <add assembly="System.Web.Helpers, Version=1.0.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35" />
        <add assembly="System.Web.Routing, Version=4.0.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35" />
        <add assembly="System.Web.Mvc, Version=3.0.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35" />
        <add assembly="System.Web.WebPages, Version=1.0.0.0, Culture=neutral, PublicKeyToken=31BF3856AD364E35" />
        <add assembly="System.Data.Entity, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089" />
      </assemblies>
    </compilation>

    <authentication mode="Windows" />

    <pages>
      <namespaces>
        <add namespace="System.Web.Helpers" />
        <add namespace="System.Web.Mvc" />
        <add namespace="System.Web.Mvc.Ajax" />
        <add namespace="System.Web.Mvc.Html" />
        <add namespace="System.Web.Routing" />
        <add namespace="System.Web.WebPages" />
      </namespaces>
    </pages>
    <httpModules>
      <add name="ErrorLog" type="Elmah.ErrorLogModule, Elmah" />
      <add name="ErrorMail" type="Elmah.ErrorMailModule, Elmah" />
      <add name="ErrorFilter" type="Elmah.ErrorFilterModule, Elmah" />
    </httpModules>
  </system.web>
  <system.webServer>
    <httpErrors errorMode="Custom" existingResponse="Replace">
      <remove statusCode="404" />
      <error statusCode="404" responseMode="ExecuteURL" path="~/error/notfound" />
      <remove statusCode="500" />
      <error statusCode="500" responseMode="ExecuteURL" path="~/error" />
    </httpErrors>
    <validation validateIntegratedModeConfiguration="false" />
    <modules runAllManagedModulesForAllRequests="true">
      <add name="ErrorLog" type="Elmah.ErrorLogModule, Elmah" preCondition="managedHandler" />
      <add name="ErrorMail" type="Elmah.ErrorMailModule, Elmah" preCondition="managedHandler" />
      <add name="ErrorFilter" type="Elmah.ErrorFilterModule, Elmah" preCondition="managedHandler" />
    </modules>
  </system.webServer>
  <runtime>
    <assemblyBinding xmlns="urn:schemas-microsoft-com:asm.v1">
      <dependentAssembly>
        <assemblyIdentity name="System.Web.Mvc" publicKeyToken="31bf3856ad364e35" />
        <bindingRedirect oldVersion="1.0.0.0-2.0.0.0" newVersion="3.0.0.0" />
      </dependentAssembly>
    </assemblyBinding>
  </runtime>
  <entityFramework>
    <defaultConnectionFactory type="System.Data.Entity.Infrastructure.SqlConnectionFactory, EntityFramework" />
  </entityFramework>
  <connectionStrings>

  </connectionStrings>
  <elmah>
    <errorLog type="Elmah.SqlErrorLog, Elmah" connectionStringName="Elmah.Sql" />
    <security allowRemoteAccess="true" />
  </elmah>
  <location path="elmah.axd" inheritInChildApplications="false">
    <system.web>
      <httpHandlers>
        <add verb="POST,GET,HEAD" path="elmah.axd" type="Elmah.ErrorLogPageFactory, Elmah" />
      </httpHandlers>

      <authorization>
        <allow roles="admin" />
        <deny users="*" />  
      </authorization>
      -->
    </system.web>
    <system.webServer>
      <handlers>
        <add name="ELMAH" verb="POST,GET,HEAD" path="elmah.axd" type="Elmah.ErrorLogPageFactory, Elmah" preCondition="integratedMode" />
      </handlers>
    </system.webServer>
  </location>
</configuration>