I have been doing web-based Javascript (vanilla JS, jQuery, Backbone, etc.) for a few years now, and recently I've been doing some work with Node.js. It took me a while to get the hang of "non-blocking" programming, but I've now gotten used to using callbacks for IO operations and whatnot.

I understand that Javascript is single-threaded by nature. I understand the concept of the Node "event queue". What I DON'T understand is what determines whether an individual javascript operation is "blocking" vs. "non-blocking". How do I know which operations I can depend on to produce an output synchronously for me to use in later code, and which ones I'll need to pass callbacks to so I can process the output after the initial operation has completed? Is there a list of Javascript functions somewhere that are asynchronous/non-blocking, and a list of ones that are synchronous/blocking? What is preventing my Javascript app from being one giant race condition?

I know that operations that take a long time, like IO operations in Node and AJAX operations on the web, require them to be asynchronous and therefore use callbacks - but who is determining what qualifies as "a long time"? Is there some sort of trigger within these operations that removes them from the normal "event queue"? If not, what makes them different from simple operations like assigning values to variables or looping through arrays, which it seems we can depend on to finish in a synchronous manner?

Perhaps I'm not even thinking of this correctly - hoping someone can set me straight. Thanks!