I've got an Apache 2.0.52 server on CentOS 4 that front-ends a couple of App servers (mix of Jetty and Tomcat). Apache has a handful of virtual hosts configured like this: <VirtualHost www1.example.com:443> ServerName www1.example.com DocumentRoot "/mnt/app_web/html" SSLEngine on SSLCipherSuite ALL:!ADH:!EXPORT56:RC4+RSA:+HIGH:+MEDIUM:+LOW:+SSLv2:+EXP SSLCertificateFile /etc/httpd/conf/ssl.crt/server.crt SSLCertificateChainFile /etc/httpd/conf/ssl.crt/chain.crt SSLCertificateKeyFile /etc/httpd/conf/ssl.key/server.key SetEnvIf User-Agent ".*MSIE.*" nokeepalive ssl-unclean-shutdown downgrade-1.0 force-response-1.0 RewriteEngine on RewriteRule ^/app1/(.*)$ http://app1.example.com:8080/app1/$1 [P,L] RewriteRule ^/app2/(.*)$ http://app2.example.com:8080/app2/$1 [P,L] </VirtualHost> However, I'm getting the following errors in the logs intermittently: [Fri Dec 04 07:19:41 2009] [error] (113)No route to host: proxy: HTTP: attempt to connect to 10.0.0.1:8080 (app1.example.com) failed I initially tried turning off IPv6, and that seemed to largely cure it, but I still have sporadic bursts of these messages. Additionally, we're running memcache on same front-end and during the times when I'm getting those messages in Apache's log, the following command doesn't work: echo stats | nc 127.0.0.1 11211 No messages are printed, but neither are the stats printed. I am completely lost as to how to proceed with troubleshooting this. =(