I'm using CSS3PIE to apply some rounded corners to elements in Internet Explorer that will get them by stylesheet in other browsers. I've run into some issues with it though.
In IE8, I discovered that any element that had the PIE behaviour would behave strangely. The container would jump a few pixels to the right, but the content would stay in its original position, giving the appearance that the content had all shifted left relative to its container. This would be especially problematic on elements with no or small amounts of padding.
I was able to hack my way around the problem in IE8 by using X-UA-Compatible, but I'd rather avoid this solution if at all possible. I don't have access to IE9 for testing but my understanding hacks like PIE aren't necessary and it would be wasteful to force a compatibility mode in a browser that doesn't need it.
I have worse issues in IE6, with the PIE layout breaking down completely on a list that is set up to use display:inline; zoom:1; list items (to simulate inline-block, which works in IE8 and the other browsers). Here the borders of the list items get rendered in completely the wrong place.
So ideally, I'd like to have PIE work properly in IE6, and in IE8 without having to resort to compatibility mode. As far as IE6 goes, a graceful fallback where PIE is just not applied will do. IE7 is the only browser where the page displays as intended.
I can't provide an example page just at the moment unfortunately, I can add one later though.
Follow up:
Here are some screen grabs made with IE Tester. I'm hoping they will make things a little more clear for everybody. As you can see, IE7 is fine. However, in IE8, the containers are offset to the left relative to their content, and in IE6 the list elements (with the rounded 1 pixel border) are a complete mess!
Full size versions for IE8, IE7 and IE6 are also available