I've done quite a bit of googling and searching here on SO, but couldn't find a similar question or answer. In typical SM configuration you can add multiple named instances for a single PluginType: ForRequestedType<IFoo>() .AddInstances( x => { x.OfConcreteType<FooA>().WithName( "FooA" ); x.OfConcreteType<FooB>().WithName( "FooB" ); } ); No problem there. The problem is that I can't do the same when creating a profile. Most examples explaining how to use profiles use the For<>() method of the passed ProfileExpression: CreateProfile( "Default", p => { p.For<IFoo>().UseConcreteType<FooC>(); } ); I can't seem to find a way to add multiple named instances for the same PluginType as you can do above with regular configuration. The only other method available through ProfileExpression is Type<>(), but I'm not sure if it can be used for this purpose. Edit: I tried to use Type<>() instead of For<>() and it seems to be taking me in the right direction, but I bumped into another problem. To better explain it here's a better example of what I'm trying to do (this is what I posted to the structuremap-users group, no answer yet): ObjectFactory.Initialize( x => { x.CreateProfile( "Nissan", p => { p.Type<ICar>().Is.OfConcreteType<NewNissanCar>().WithName( "New" ); p.Type<ICar>().Is.OfConcreteType<OldNissanCar>().WithName( "Old" ); } ); x.CreateProfile( "Honda", p => { p.Type<ICar>().Is.OfConcreteType<NewHondaCar>().WithName( "New" ); p.Type<ICar>().Is.OfConcreteType<OldHondaCar>().WithName( "Old" ); } ); } ); ObjectFactory.Profile = "Nissan"; ICar newCar = ObjectFactory.GetNamedInstance<ICar>( "New" ); // -> returns NewHondaCar ICar car = ObjectFactory.GetInstance<ICar>(); // -> returns OldNissanCar So even though I set the profile to "Nissan", GetNamedInstance<>("New") returned an instance from the incorrect profile - it should've returned NewNissanCar instead of NewHondaCar. Interestingly, GetInstance<>() uses the correct profile, but because I can't pass an instance name, it returns an arbitrary concrete type from that profile that implements ICar (I guess it just returns the last concrete type added for that interface).