I don't know how to properly describe what I need to do, so I will give an example. A colleague has a data set in Excel like so: Col A Col B Col C aaaaa aaaaa bbbbb bbbbb ccccc ccccc ccccc ddddd eeeee The end result should be something like this: Col A Col B Col C aaaaa aaaaa bbbbb bbbbb ccccc ccccc ccccc ddddd eeeee Or even: Col A Col B Col C aaaaa Yes Yes No bbbbb Yes No Yes etc. (if it helps, the columns are protein extraction methods and the letters are protein IDs - we need to determine which proteins are extracted by which methods) My colleague is doing this by hand, but there is enough data that it would be really helpful to automate it. Is there a formula in Excel to do this automatically?