The problem? Performing a build on a ClickOnce solution would not be successful due to the setup.bin not being located. Ok, now what? Researched from corner to corner, install, re-install, update. Found some interesting posts to fix the issue, but most of them were focused on Team Foundation Server/Team Build 2008, and some other on 2005. The other interesting tidbit was the frequent indication to modify the registry to help Team Build find the bootstrapper. Background info: This was a migration I posted about a few days ago, a 32 bit TFS implementation to a full 64 bit TFS implementation. Now, the project has binaries and dependencies on X86 (This piece of information became essential to moving from a failed build to a successful build). So, what’s the fix? The trick in this case was to go back into the Build Type and check the properties/configuration. Upon further investigation, I found the following: Once you Edit the Build Definition, then select Process, expand 3. Advanced and look for MSBuild Platform, switch from Auto to X86. Ran the Build, and success!