Sooner or later, coders will feel the need to have access to "open data" in one of their projects, from knowing a city's zip to a more obscure information such as the axial tilt of Pluto.
I know data.un.org which offers access to the UN's extensive array of databases that deal with human development and other socio-economic issues. The other usual suspects are NASA and the USGS for planetary data. There's an article at readwriteweb with more links. infochimps.org seems to stand out.
Personally, I need to find historic commodity prices, stock values and other financial data. All these data sets seem to cost money however.
Clarification
To clarify, I'm interested in all kinds of open data, because sooner or later, I know I will be in a situation where I could need it. I will try to edit this answer and include the suggestions in a structured manners.
A link for financial data was hidden in that readwriteweb article, doh! It's called opentick.com. Looks good so far!
Update
I stumbled over semantic data in another question of mine on here. There is opencyc ('the world's largest and most complete general knowledge base and commonsense reasoning engine'). A project called UMBEL provides a light-weight, distilled version of opencyc. Umbel has semantic data in rdf/owl/skos n3 syntax.
The Worldbank also released a very nice API. It offers data from the last 50 years for about 200 countries
