I have a friend who uses Windows 7 for her home PC.
She has a RAID1 array that is using up-to-date Intel Matrix storage drivers, and the entire array is backed up to a separate internal SATA HDD via Acronis True Image every night.
Over the weekends, she lets her machine go into suspend after 4 hours of inactivity, and then later into hibernation after 6 hours of inactivity.
Her Acronis backup system does nightly incremental backups, and full backups every Saturday night. She also has AVG Free Antivirus installed which does full scans every Monday.
So far, on two occasions, on Sunday morning, her user profile is corrupt. I couldn't find any solution that allowed me to repair her profile, so I end up having to (as suggested by MS Knowledge Base, http://windows.microsoft.com/en-us/windows7/fix-a-corrupted-user-profile ;, Yep, no solution to fixing it, just clobber the whole thing) recreating her profile, then copying over data, recreating her Outlook profile, reconfiguring all third-party applications, etc. It's a real nightmare, and takes 4 hours to do each time.
Are there any suggestions on how to resolve this profile corruption? This was happening even before the RAID/Acronis solution was in place, but I thought I'd provide as much information as possible.