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  • hierarchical clustering with gene expression matrix in python

    - by user248237
    how can I do a hierarchical clustering (in this case for gene expression data) in Python in a way that shows the matrix of gene expression values along with the dendrogram? What I mean is like the example here: http://www.mathworks.cn/access/helpdesk/help/toolbox/bioinfo/ug/a1060813239b1.html shown after bullet point 6 (Figure 1), where the dendrogram is plotted to the left of the gene expression matrix, where the rows have been reordered to reflect the clustering. How can I do this in Python using numpy/scipy or other tools? Also, is it computationally practical to do this with a matrix of about 11,000 genes, using euclidean distance as a metric? thanks.

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  • Mac OS X Lion 10.7.2 update breaks SSL

    - by mcandre
    Summary After updating from 10.7.1 to 10.7.2, neither Safari nor Google Chrome can load GMail. Spinning Beachballs all around. The problem isn't GMail; Firefox loads GMail just fine. The problem isn't limited to Safari or Google Chrome; Other applications also have trouble with SSL: Gilgamesh and Safari. Any program that uses WebKit (Google Chrome, Safari) or a Cocoa library (Gilgamesh) to access the Internet has trouble loading secure sites. The various forums online suggest a handful of fixes, none of which work. Analysis Fix #1: Open Keychain Access.app and delete the Unknown certificate. The 10.7.2 update also prevents Keychain Access from loading. The Keychain program itself Spinning Beachballs. Fix #2: Delete ~/Library/Keychains/login.keychain and /Library/Keychains/System.keychain. This temporarily resolves the issue, and lets you load secure sites, but a minute or two after rebooting or hibernating somehow magically undoes the fix, so you have to delete these files over and over. Fix #3: Delete ~/Library/Application\ Support/Mob* and /Library/Application\ Support/Mob*. There is a rumor that the new MobileMe/iCloud service ubd is causing the issue. This fix does not resolve the issue. Fix #4: Open Keychain Access, open the Preferences, and disable OCSP and CRL. This fix does not resolve the issue. Fix #5: Use the 10.7.0 - 10.7.2 combo installer, rather than the 10.7.1 - 10.7.2 installer. When I run the combo installer, it stays forever at the "Validating Packages..." screen. The combo installer itself is bugged to He||. I force-quit the installer, ran "sudo killall installd" to force-quit the background installer process, and reran the combo installer. Same problem: it stalls at "Validing Packages..." Recap The only fix that works is deleting the keychains, but you have to do this every time you reboot or wake from hibernate. There is some evidence that ubd continually corrupts the keychain files, but the suggested ubd fix of deleting ~/Library/Application\ Support/Mob* and /Library/Application\ Support/Mob* does not resolve this issue. Evidently, something is corrupting the keychain over and over and over. Also posted on the Apple Support Communities.

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  • Developer tool for configuring IIS6

    - by Marc Gravell
    edit: IIS6; I'm not sure IIS7 is an option in the immediate future... From a developer angle, I am constantly changing my IIS settings, or need to merge settings from other teams into different VMs. The "Save Configuration to Disk" has never really worked well for me. Because we are making lots of small changes, web installation projects have never really worked either... Tools aimed for the web-admin aren't necessarily a good fit for the developer - we have different aims and needs. Does anyone have a script / tool / utility that would allow us to quickly configure IIS? In particular: remove everything (start clean) add a load of virtual directories, each mapped to application base paths set as an application set the app-pool (we'll assume the app pool already exists) set the ASP.NET version to 2.x if needed from some find of flat input list (any format would do).

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  • Creating an installer with WPF forms, packaged files and custom setup actions

    - by RodH257
    I'm trying to create a way of deploying a set of tools (which are add-ins to 3rd party software) to my users. I would like to do the following: User Enters Serial Dlls in their directory structure is extracted to program files a file is copied to a location in ProgramData (this registers my add-ins to the 3rd party application) Online activation for software is performed Can anyone point me into the right direction for this? I had a look at deployment projects in Visual Studio but I'm not sure if they are what I'm after. Main problem is they are ugly, I would like to have a nice WPF installer, and have a more custom experience. But I guess that can be traded off if its going to make things easier. I was thinking, I could just make my own C# project that extracts the files, but I have no idea how to package them up and extract them all as part of one download (like the MSI files that the deployment projects create). Can anyone point me in the right direction?

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  • How to synchronize SQL Server 2008 database with SQL Server 2005 database?

    - by James McFarland
    I am using VS 2008 Team Suite and SQL Server 2008 in my development environment. I am deploying to a shared-host website with shared-host SQL Server 2005. I want to push changes from my development environment to my production host. I tried using Data | Schema Compare... and it reports to me that it does not support SQL Server 2008. What do people use for this (Besides Red-Gate tools - I use those at my day job, and they rock...this is a volunteer thing for my son's school)? I am looking for something very inexpensive if not free.

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  • How can I find which process has opened a specific file?

    - by Hosam Aly
    How can I find which processes have a specific file opened, and their open, access and share modes? Additionally, is it possible to change these values for a process? Or is it even possible to open a file for reading if it is already opened for exclusive access by another process? Please note that I don't want to invalidate the handle of the process having the file opened. I just want to be able to access the file (if possible). (I'm mainly asking about Windows, but solutions for other platforms are welcome, since they contribute to the community's knowledge.) Edit: I found some answers for my first question here and there. Edit 2: Thanks everybody for the tools you mentioned, but I am mainly looking for programmatical techniques (e.g. using Win32 APIs).

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  • Is there a 3 way merger tool that “understands” common refactoring?

    - by Ian Ringrose
    When a simple refactoring like “rename field” has been done on one branch it can be very hard to merge the changes into the other branches. (Extract method is much harder as the merge tools don’t seem to match the unchanged blocks well) Now in my dreams, I am thinking of a tool that can record (or work out) what well defined refactoring operations have been done on one branch and then “replay” them on the other branch, rather than trying to merge every line the refactoring has affected. see also "Is there an intelligent 3rd merge tool that understands VB.NET" for the other half of my pain! Also has anyone try something like MolhadoRef (blog article about MolhadoRef and Refactoring-aware SCM), This is, in theory, refactoring-aware source control.

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  • Why doesn't my CreateRibbonExtensibilityObject method get called?

    - by DGGenuine
    Hi I've been tinkering around with the two techniques to modify the ribbon with an MS Word addin (Visual Studio 2010, .NET 3.5), a Microsoft.Office.Tools.Ribbon.OfficeRibbon and Microsoft.Office.Core.IRibbonExtensibility. I was hoping to switch between the two in my addin's CreateRibbonExtensibilityObject, but for some reason it is not called now. The documentation says that if an addin implements CreateRibbonExtensibilityObject that it will be called. When I create a fresh project to test doing this very thing, it works. I'd prefer not to abandon my project as-is. Any ideas? Thank you.

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  • Generate PDF - how to create paged HTML content beforehand?

    - by Alt_Doru
    My task is to create ready-to-print invoices from a .NET web app. I am already generating the printer-friendly HTML for an invoice - it consists of an invoice header (that will actually need to appear on each printed page) and invoice positions (that may span multiple printed pages). Now, my task is to generate a PDF server-side, populate a header on each of its pages, then populate its pages with invoice positions. I need to generate the PDF from the existing HTML data - by simply passing HTML input to the PDF generator library. I've started using ABCPDF - I am using the AddImageHtml method. The problem I have is that ABCPDF seems to expect me to supply HTML content already paged. So, it won't work correctly when I feed it HTML content that would span on more than 1 PDF page. So, my question is - do you have any suggestions on making this work with ABCPDF? Or, more generally speaking, what other tools/approaches would you use for this - generating PDF doc with headers/footers from HTML input? Thanks

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  • jQuery/Javascript framework efficiency

    - by Russell
    My latest project is using a javascript framework (jQuery), along with some plugins (validation, jquery-ui, datepicker, facebox, ...) to help make a modern web application. I am now finding pages loading slower than I am used to. After some js profiling (thanks VS2010!), it seems a lot of the time is taken procesing inside the framework. Now I understand the more complex the ui tools, the more processing needs to be done. The project is not yet at a large stage and I think would be average functions. At this stage I can see it is not going to scale well. I noticed things like the 'each' command in jQuery takes quite a lot of processing time. Have others experienced some extra latency using JS frameworks? How do I minimise their effect on page performance? Are there best practices on implementation using JS frameworks? Thanks

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  • How To Access Namespace Elements In MXML Using Actionscript

    - by Joshua
    In Actionscript... If I Have an XML variable that equals this: var X:XML=XML("<mx:WindowedApplication xmlns:mx="http://www.adobe.com/2006/mxml" layout="vertical" xmlns:ns1="Tools.*" minWidth="684" minHeight="484" creationComplete="Init();" xmlns:ns3="Components.*" initialize="I()"/>"); And I try to list the attributes via: var AList:XMList=X.attributes(); The three namespaces, "xmlns:mx","xmlns:ns1", and "xmlns:ns3" aren't listed among the attributes! How can I access this information programmatically?

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  • Display content in folder like Wordpress displays Themes

    - by Mestika
    Hi, I’ve throughout the last couple of years downloaded a lot of templates for websites and these are now starting to become chaotic in the different folders so I’m starting to get a overview of the different templates. Regarding to this I was thinking about the way that WordPress displays the different themes installed in the themes folder. It provides a small overview (thumbnail) of the theme and a possibility to preview the theme. Of cause, I don’t need or want such a advanced system as Wordpress but I’m attractive to the idea of displaying my templates in the same kind of manner and without using a Database. I’ve played around with different directory management scripts and tools for PHP but the best result I’ve got so fare is just to display the different content in the different folders but not create a preview which in each preview it will use the webpage itself and it’s stylesheets, images, etc. Does anyone have an idea how to create such a script or have a link to a already existing script. Of cause is all the main pages named index.htm / .html Sincere Mestika

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  • JetBrains dotTrace, is it possible to profile source code line by line? else I need another tool

    - by m3ntat
    I am using JetBrains dotTrace, I've profiled my app which is entirely CPU bound. But the results as you walk down the tree don't sum to the level above in the tree, I only see method calls not the body lines of the node in questions method. Is it possible to profile the source code line by line. i.e for one node: SimulatePair() 99.04% --nextUniform() 30.12% --IDCF() 24.08% So the method calls nextUniform + IDCF use 54% of the time in SimulatePair (or 54% total execution time I'm not sure how to read this) regardless what is happening the other 46% of SimulatePair I need some detail on a line by line basis. Any help or alternative tools is much appreciated. Thanks

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  • MooTools Fx.Slide throwing this.element is null

    - by Brant
    The following code is throwing the error "this.element is null". However, the wid_cont is definitely grabbing an element. window.addEvent('domready',function(){ var min = $(document.body).getElements('a.widget_minimize'); min.addEvent('click', function(event){ event.stop(); //var box = ; var wid_cont = ($(this).getParents('.widget_box').getElement('.widget_box_content_cont')); var myVerticalSlide = new Fx.Slide(wid_cont); myVerticalSlide.slideOut(); } ); }); It's moo tools 1.2.4 and has the fx.slide included....

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  • OpenType programming

    - by Sorush Rabiee
    Hi all Recently i asked two questions (1 and 2) about using OpenType features in programs written by python and .net languages, but didn't get an answer. i realized there is no way to change text rendering engines of operating systems, or force them to use OpenType. so now want to implement my own. such a program that: provides a text engine that receives glyph shapes from otf and ttf files and renders them in sequence of glyphs in text. generates all of OTL features can be used in other parts of applications like controls and components of .NET or python GUI libraries. if python and .net languages are not suitable in this situation, aware me about other programming languages or tools. comments and answers about text rendering system of common Operating Systems, or designing text engines compatible with unicode 5.02 protocol are welcomed.

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  • Which C# / .NET free or standard bits and pieces do I need to make a simple Windows desktop app back

    - by jjujuma
    I'm coming from a Java / web background with no C# experience and I want to write a prototype C# / .NET desktop app to run against my existing DB2 database. The idea is that the prototype should use libraries and tools which are suitable for scaling up to full production and should be standard and free. Of the top of my head, the two biggest things I need are: an IDE a GUI toolkit / set of components a JDBC equivalent and/or possibly a full blown ORM system What are my options? Note I don't mind paying for full blown Visual Studio in the long run, but for now everything needs to be free, including the IDE.

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  • ArgumentOutOfRangeException at MySql execution. (MySqlConnector .NET)

    - by Lazlo
    I am getting this exception from a MySqlCommand.ExecuteNonQuery(): Index and length must refer to a location within the string. Parameter name: length The command text is as follows: INSERT INTO accounts (username, password, salt, pin, banned, staff, logged_in, points_a, points_b, points_c, birthday) VALUES ('adminb', 'aea785fbcac7f870769d30226ad55b1aab850fb0979ee00481a87bc846744a646a649d30bca5474b59e4292095c74fa47ae6b9b3a856beef332ff873474cc0d3', 'cb162ef55ff7c58c7cb9f2a580928679', '', '0, '0', '0', '0', '0', '0', '2010-04-18') Sorry for the long string, it is a SHA512 hash. I tried manually adding this data in the table from MySQL GUI tools, and it worked perfectly. I see no "out of range" problem in these strings. Does anybody see something wrong?

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  • imagejpeg memory exhaustion

    - by 0plus1
    I'm creating thumbnails cycling through a lot of images, when I find a large image I get: Fatal error: Allowed memory size of 33554432 bytes exhausted (tried to allocate 13056 bytes) Now I already know how to circumvent this with: ini_set('memory_limit', '-1'); What I want to know is why it exhaust the memory! Is there some debug tools that will show me exactly when memory is exhausting? And specifically that will show me if there are variables/arrays that are killing my memory? OR, are there better way to resize images other then: $thumb=imagecreatetruecolor($newwidth,$newheight); $source=imagecreatefromjpeg($imgfile); imagecopyresampled($thumb,$source,0,0,0,0,$newwidth,$newheight,$width,$height); imagejpeg($thumb,$destinationfile,85); ? Thank you very much!

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  • What's the best way to view/analyse/filter huge traces/logfiles?

    - by oliver
    this seems to be a reoccurring issue: we receive a bug report for our software and with it tons of traces or logfiles. since finding errors is much easier when having a visualization of the log messages/events over time it is convenient to use a tool that can display the progression of events in a graph etc. (e.g. wireshark (http://www.wireshark.org) for analyzing network traffic) what tool do you use for such a purpose? the problem with most tools i used so far is that they mercilessly break down when you feed them huge data traces ( 1GB) so some criteria for such a tool would be: can deal with huge input files ( 1 GB) is really fast (so you don't have to get coffee while a file is loading) has some sort of filtering mechanism

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  • Trying to verify understanding of foreign keys SQL Server

    - by msarchet
    So I'm working on just a learning project to expose myself to doing some things I do not get to do at work. I'm just making a simple bug and case tracking app (I know there are a million this is just to work with some tools I don't get to). So I was designing my database and realized I've never actually used Foreign Keys before in any of my projects, I've used them before but never actually setting up a column as a FK. So I've designed my database as follows, which I think is close to correct (at least for the initial layout). However When I try to add the FK's to the linking Tables I get an error saying, "The tables present in the relationship must have the same number of columns". I'm doing this by in SQLSMS by going to the Keys 'folder' and adding a FK. Is there something that I am doing wrong here, I don't understand why the tables would have to have the same number of columns for me to add a FK relationship between the tables?

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  • Determining full XHR request URL on a Google Chrome XHR Breakpoint

    - by DanH
    I am initiating a jQuery ajax ($.ajax) post, within the Google Chrome browser. I have setup a XHR breakpoint in the "XHR Breakpoints" section of the "Scripts" tab within the Developer Tools. The criteria of the breakpoint is "get" ie. I want the debugger to break on all XHR requests which contain the word "get" in them (somePage.asmx/getListOfAnimals) is an example. The breakpoint is being correctly hit, however I am unable to determine what the exact URL that is being requested. I realize I can remove the breakpoint and see what URL is being requested from the "Network" tab, but I want to know this at the time the breakpoint is hit. I have tried stepping through the XHR request once it has been hit in Chrome, but I must be missing a Javascript object/property which contains the fully requested URL. Google Chrome has detected that the XHR requested URL contains "get" but how do I get to this URL from within the debug session before the request is made?

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  • Dynamic Jquery Accordion

    - by kwek-kwek
    How do I default an accordion to be closed on start-up. here is the sample view here Here is the code: <script> $(function() { $("#accordion").tabs("#accordion div.pane", {tabs: 'h3', effect: 'slide'}); }); </script> <script> // add new effect to the tabs $.tools.tabs.addEffect("slide", function(i, done) { // 1. upon hiding, the active pane has a ruby background color this.getPanes().slideUp("slow").css({backgroundColor: "#fff"}); // 2. after a pane is revealed, its background is set to its original color (transparent) this.getPanes().eq(i).slideDown("slow", function() { $(this).css({backgroundColor: 'transparent'}); // the supplied callback must be called after the effect has finished its job done.call(); }); }); </script>

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  • ec2_bundle_vol fails with error LoadError

    - by Koran
    Hi, I am a newbie in amazon ec2 setup. I have now setup a machine to my taste - and I now want to bundle it. I am running the following command from the launched instance - root@domU-21-34-67-26-ED-Z4:~# ec2-bundle-vol -r i386 -d /mnt \ -p ACT-VOL -u 8940-1355-4155 -k /tmp/pk-key.pem \ -c /tmp/cert.pem -s 10240 \ -e /mnt,/root/.ssh,/home/ubuntu/.ssh ruby: No such file or directory -- /home/ubuntu/ec2tools/ec2-api-tools-1.3-46266/lib/ec2/amitools/bundlevol.rb (LoadError) The ruby version is 1.8.7. I searched internet and installed libruby1.8-extras etc too, but to no avail. I also tried running it from site_ruby (/usr/local/lib/site_ruby) - but no use. I tried installing 1.8.6 version of ruby, but was unable to find a way to do so too. Any help would be much appreciated. Thanks, K

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  • FileNotFound Exception when using TestDriven.NET and NUnit

    - by Quang Anh
    I'm Writing a simple pong game in C# and XNA 4.0 to learn unit testing. The tools used are TestDriven.NET and NUnit, all newest versions. The problem is, if I test the code with VS2010 internal debugger, everything runs fine, but when I use "Run Test(s)" from menu, the application chokes with error: Test 'WindowsGame1.Game1.TestGameMenu' failed: Microsoft.Xna.Framework.Content.ContentLoadException : Error loading "SpaceBackground". File not found. ----> System.IO.FileNotFoundException : Error loading "Content\SpaceBackground.xnb". File not found. (some more below...) So it stops when the first textre is going to be loaded. What's going on? If you want to check the code out, download it here http://www.mediafire.com/?qwnkmyqheum

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  • Setting up DomainKeys/DKIM in a PHP-based SMTP client

    - by Alex
    It looks like there are some great libraries out there to do DomainKeys signing of emails on C#/.NET, but I'm having a really hard time finding the same kind of support for PHP. Maybe I'm not looking in the right place? The only one I found is http://php-dkim.sourceforge.net/; it looks incredibly hacky and supports PHP4 only. Considering how popular PHP is, and how critical DomainKeys are for email classification as non-spam, I'd expect better tools; do you know of any? Any other tricks you'd recommend?

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