While I've never delivered anything using Smalltalk, my brief time playing with it has definitely left its mark. The only way to describe the experience is MVC the way it was meant to be. Essentially, all the heavy lifting for your application is done in the business objects (or domain model if you are so inclined). The standard controls are bound to the business objects in some way. For example, a text box is mapped to an object's field (the field itself is an object so it's easy to do). A button would mapped to a method. This is all done with a very simple and natural API. We don't have to think about binding objects, etc. It just works.
Yet, in many newer languages and APIs you are forced to think from the outside in. First with C++ and MFC, and now with C# and WPF, Microsoft has gotten it's developer world hooked on GUI builders where you build your application by implementing event handlers. Java Swing development isn't so different, only you are writing the code to instantiate the controls on the form yourself. For some projects, there may never even be a domain model--just event handlers. I've been in and around this model for most of my carreer.
Each way forces you to think differently. With the Smalltalk approach, your domain is smart while your GUI is dumb. With the default VisualStudio approach, your GUI is smart while your domain model (if it exists) is rather anemic.
Many developers that I work with see value in the Smalltalk approach, and try to shoehorn that approach into the VisualStudio environment. WPF has some dynamic binding features that makes it possible; but there are limitations. Inevitably some code that belongs in the domain model ends up in the GUI classes.
So, which way do you design/develop your code? Why?
GUI first. User interaction is paramount.
Domain first. I need to make sure the system is correct before we put a UI on it.
There's pros and cons for either approach. Domain model fits in there with crystal cathedrals and pie in the sky. GUI fits in there with quick and dirty (sometimes really dirty).
And for an added bonus: How do you make sure the code is maintainable?