Is autohotkey capable of interpreting hotkeys in the style of Ctrl + Shift + W, W? I would assume a script like the following would work: ^+W:: ; Windows hotkeys (Ctrl + Shift + W) O:: Run Outlook ; Subsequent 'o' pressed => Run outlook E:: Run Explorer ; return From the documentation I note that these are called vertically stacked hotkeys and cause each line to perform the same action. In the case above, I think Ctrl+Shift+W and o will both cause outlook to be launched, whereas pressing e would cause explorer to be launched. What I would like is Ctrl+Shift+W, O runs outlook and Ctrl+Shift+W, e runs windows explorer. Is there any way to cause a hotkey to perform context specific actions (much like in Eclipse), where I can press Ctrl+Shift+W to activate a block of specific hotkeys?