I have a very similar case as this user: Access denied on some files on Win2008R2 DC share This is on a windows 2008 R2. The user has Win7 pro. The user has their own home folder on the server. Every file, except one, the user can read/write/modify at their own will. No problems - except this one file. She gets "access denied" I can open it (as domain admin). Another user can open it (because she's in the domain admin group). I did run the AccessEnum tool and the read/write permissions are all identical for all files. So, I can't explain why the user can't open this one single file. Out of all her files in sub-folders and such. No problems. This one file is causing a headache. What do you think could be wrong here?