I am working on a long running Python program (a part of it is a Flask API, and the other realtime data fetcher). Both my long running processes iterate, quite often (the API one might even do so hundreds of times a second) over large data sets (second by second observations of certain economic series, for example 1-5MB worth of data or even more). They also interpolate, compare and do calculations between series etc. What techniques, for the sake of keeping my processes alive, can I practice when iterating / passing as parameters / processing these large data sets? For instance, should I use the gc module and collect manually? Any advice would be appreciated. Thanks!