I'm looking for a concise and functional style way to apply a function to one element of a tuple and return the new tuple, in Python. For example, for the following input: inp = ("hello", "my", "friend") I would like to be able to get the following output: out = ("hello", "MY", "friend") I came up with two solutions which I'm not satisfied with. One uses a higher-order function. def apply_at(arr, func, i): return arr[0:i] + [func(arr[i])] + arr[i+1:] apply_at(inp, lambda x: x.upper(), 1) One uses list comprehensions (this one assumes the length of the tuple is known). [(a,b.upper(),c) for a,b,c in [inp]][0] Is there a better way? Thanks!