I can't open any PDFs in IE10 on Win7 64bit. I've tested with PDFs from Intranet / Internet / local file system, http and https. I've tested installing/uninstalling Acrobat Reader 11.0.03 and the Nitro PDF Reader. I've also tried enabling/disabling the Tools Internet Options Advanced Security Do not save encrypted pages to disk option. In Google Chrome PDFs are opened in the Acrobat Reader Plugin, but in IE10 the only thing I always get is a small cross in the top left corner of the browser. Can anybody help me?