The problem When I try to make a AJAX partial update request (using the UpdatePanel control) from the default page of an IIS7 web site, it fails- instead of returning the html to be updated, it returns the entire page, which then causes the MS AJAX Javascript to throw a parsing shit-fit. The suspected cause I have narrowed the cause down to two issues- making an AJAX request to the default page when I have a certain custom http module registered. A partial rendering request to http://localhost will fail, but a partial rendering request to http://localhost/default.aspx will work fine. Also, If i remove the following line in my custom HttpModule: _application.PreRequestHandlerExecute += OnPreRequestHandlerExecute; The AJAX partial render will work correctly. Wierd huh? Another wierd thing... If I look at trace.axd, I can see that when a partial rendering request fails, two POST requests are logged for the one partial rendering request- one where the default.aspx page executes successfully (trace information such as page_load is logged) but no content is produced and a second that doesn't seem to actually execute (no trace information is logged) but produces content (HTTP_CONTENT_LENGTH is greater than 0). Please help! If anyone with a good knowledge of HTTP modules or the MS AJAX Http module could explain why this is occuring I would be very grateful. As it is, the obvious work arround is to just redirect to default.aspx if the request url is "/" but I would really like to understand why this is occurring.