I've been running a campaign for about a year and a half now and the campaign has been setup by location. I'd have one campaign targeted for a specific region. And then I would duplicate the ad groups for each campaign. I have 5 ad groups targeting different areas of my business).

This has worked reasonably well.

It just occurred to me that it might easier if the campaign structure were reversed: 5 campaigns: each campaign focused on a different area of business and divided into 20+ adgroups (based on location).

Will this screw up my campaign if I switch the structure? I have 10's for QS and I don't want to lose that!