When you try to install MOSS 2007 on Windows 2008 R2, if you are using an installation media that is older than SP2, you would get the following error, saying that “This program is blocked due to compatibility issues” All is not lost though, all you need to do is to slip stream the SP2 updates to the MOSS 2007 Setup. Here’s a nice how to on how to do that. http://blogs.technet.com/seanearp/archive/2009/05/20/slipstreaming-sp2-into-sharepoint-server-2007.aspx Once you slipstream the SP2 updates, you would be able to continue with the installation with out the above error. HTH. You may already read from blogs about April Cumulative Update for separate components in SharePoint. Now, the server-packages (also known as “Uber” packages) of April Cumulative Update for Microsoft Office SharePoint Server 2007 and Windows SharePoint Services 3.0 are ready for download. Download Information Windows SharePoint Services 3.0 April cumulative update package http://support.microsoft.com/hotfix/KBHotfix.aspx?kbnum=968850 Office SharePoint Server 2007 April cumulative update package http://support.microsoft.com/hotfix/KBHotfix.aspx?kbnum=968851 Detail Description Description of the Windows SharePoint Services 3.0 April cumulative update package http://support.microsoft.com/kb/968850 Description of the Office SharePoint Server 2007 April cumulative update package http://support.microsoft.com/kb/968851 Installation Recommendation for a fresh SharePoint Server To keep all files in a SharePoint installation up-to-date, the following sequence is recommended. Service Pack 2 for Windows SharePoint Services 3.0 Service Pack 2 for Office SharePoint Server 2007 April Cumulative Update package for Windows SharePoint Services 3.0 April Cumulative Update package for Office SharePoint Server 2007 Please note: Start from April Cumulative Update, the packages will no longer install on a farm without a service pack installed. You must have installed either Service Pack 1 (SP1) or SP2 prior to the installation of the cumulative updates. After applying the preceding updates, run the SharePoint Products and Technologies Configuration Wizard or “psconfig –cmd upgrade –inplace b2b -wait” in command line. This needs to be done on every server in the farm with SharePoint installed. The version of content databases should be 12.0.6504.5000 after successfully applying these updates. For more in-depth guidance for the update process, we recommend that customers refer to the following articles. These articles provide a correct way to deploy updates, identify known issues (and resolutions), and provide information about creating slipstream builds. Deploy software updates for Windows SharePoint Services 3.0 http://technet.microsoft.com/en-us/library/cc288269.aspx Deploy software updates for Office SharePoint Server 2007 http://technet.microsoft.com/en-us/library/cc263467.aspx Create an installation source that includes software updates (Windows SharePoint Services 3.0) http://technet.microsoft.com/en-us/library/cc287882.aspx Create an installation source that includes software updates (Office SharePoint Server 2007) http://technet.microsoft.com/en-us/library/cc261890.aspx